Feb. 4, 2015
Time: 11:00AM EST/8:00AM PST
Length: 60 min.
In this webinar we present a comprehensive suite of analytical techniques based
on light scattering. These essential R&D tools are vital to the biophysical
characterization of macromolecules such as proteins and polymers, as well as
VLPs, viruses and other nanoparticles that constitute modern vaccines.
Case studies will show how multi-angle light scattering
(MALS) and dynamic light scattering (DLS) instrumentation - whether in
standalone mode or in combination with a separation system, such as SEC or FFF
– solve key analytical challenges in vaccine development, formulation and
quality control.
Learning Objectives:
- Determination
of molar mass, size and composition for biopolymers and protein-polysaccharide
conjugate vaccines, by SEC-MALS
- High-resolution
characterization of size, conformation and composition of virus, VLP, liposome,
and emulsion nanoparticles, by FFF-MALS
- High-throughput vaccine formulation and
stability studies, by plate-based DLS
- Label-free, immobilization-free analysis of
antigen-antibody and more complex biomolecular interactions, by CG-MALS
Who Should Attend:
- R&D managers who encounter common challenges
associated with biophysical characterization.
- Researchers interesting in learning about new
analytical techniques applicable to vaccine research and development.
- Project Supervisors needing more information
about cutting-edge technology for biopolymer and nanoparticle characterization.
Speaker:
Michelle Chen, Ph.D., Head of Analytical Services, Wyatt Technology Corporation
Dr. Chen is the Director of Analytical Services at Wyatt Technology Corp., overseeing new application development, sample analysis services at Wyatt’s Application Lab, technical sales support and instrument quality control. She graduated from
the Chemical Engineering Department of Yale University, where her doctoral work focused on the development of novel approaches for high-speed and high-efficiency liquid chromatography of biopolymers.
Since joining Wyatt Technology in 1996, Dr. Chen has relentlessly pursued new ways of characterizing synthetic and biological polymers by incorporating multi-angle light scattering and dynamic light scattering detection with HPLC and field flow fractionation.